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Universidad Nacional del Litoral
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| Presentation | |
The
Virology Laboratory from the Universidad Nacional del Litoral is headed by Dr. Juan Daniel Claus and is composed of the following members: Its mains thematics are the optimization of viral production processes in animal cell cultures, the design of serum-free and animal-free culture media for animal cell cultures, the development of microbial insecticides and the virus inactivation. The team has the following equipment at its disposal: |
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| Role in the project | |
Objectives:
- To establish master banks of cell lines and viral vectors. - To establish a vector production platform. - To provide enough amounts of high quality viral vectors for immunological evaluation. - To optimize the production of viral vectors. |
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| Scientific manager | |
Dr. Juan Daniel Claus is Associate Professor of Biotechnology, by the
Facultad de Bioquímica y Ciencias Biológicas,
Universidad Nacional del Litoral. |
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| Education: · Degree: Biochemistry (Universidad Nacional del Litoral, 1983). · Post-degree: PhD (Universidad de Buenos Aires, 1997). |
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| Recent Publications:
· Imaz, M.S., Comini, M.A., Zerbini, E., Sequeira, M.D., Spoletti, M.J., Etchart, A.A., Pagan, H.J., Bonifasich, E., Díaz, N., Claus, J.D., and Singh, M. (2001). Evaluation of the diagnostic value of measuring IgG, IgM and IgA antibodies to the recombinant 16-kilodalton antigen of Mycobacterium tuberculosis in childhood tuberculosis. International Journal of Tubercle and Lung Diseases, 5: 1036 – 1043. · Claus, Juan Daniel and Cap de Sciocco, Alicia (2001) Producción masiva de baculovirus. En: Los Baculovirus y sus aplicaciones como bioinsecticidas. Eds.: P. Caballero, M. López Ferber y T. Williams. Agro-publi y Universidad de Navarra, España, p. 257 - 312. · Visnovsky, G, Claus, J. D. and Merchuk, J. C. (2003) Optimization of the culture of insect cells for the production of viral-based pesticides in airlift reactors: Influence of geometrical design and superficial gas velocity. Latin America Applied Research 33 (3): 207-212. · Imaz, M.S., Comini, M.A., Zerbini, E., Sequeira, M.D., Latini, O., ClausJ.D. and Singh, M. (2004) Evaluation of Commercial ELISA Kits for the Detection of Tuberculosis in Argentinean population. J. Clin. Microbiol. 42 (2): 884-887. · Claus, J.D. and Gioria, V. (2004) Protein hydrolysates as raw materials for producing a viral bioinsecticide in lepidopteran insect cell cultures. In: Biotechnological Advances and Applications in Bioconversion of Renewable Raw Materials. R. Jonas, A. Pandey and G. Tharun, Eds. GBF and Inwent. Braunschweig, Germany, p. 108-112. · Coto, C. E. and Claus, J. D. Vacunas virales: bases científicas para su diseño. En: Microbiología Médica (2da Edition), Eds.: J. Basualdo, C. Coto y R. de Torres, Atlante, Buenos Aires, p 456-490. · Gioria, V., Jáger, V., and Claus, J.D. Growth, metabolism and baculovirus production in suspension cultures of an Anticarsia gemmatalis cell line. Cytotechnology, 52 (2): 113-124. |
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| Patents: · Claus, J.D., Comini, M.A., Perín, J.C., Salvetti, J. C., Tonarelli, G, Frank, R. (9/10/2000) Casein-Peptidfragments mit wachstumsbeeinflussender Aktivität auf Zellkulturen. Deutsche Patentanmeldung DE 100 50 091.9. · Claus, J.D., Comini, M.A., Perín, J.C., Salvetti, J. C., Tonarelli, G, Frank, R. (2003) Casein Peptide Fragments with Growth-Influencing Activity on Cell Cultures. PCT/DE01/03849. |
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| Contact | |
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Universidad Nacional del Litoral |
